Yeast - Reference Chromosome III

mips


Nature 357: 38-46 (1992) [92244356]

The complete DNA sequence of yeast chromosome III

Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.A., Bolotin-Fukuhara M., Brown A.J.P., Brown R., Buhler J.M., Carignani G., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., De Haan M., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Düsterhöft A., Erdmann D., Esteban M., Fabre F., Fairhead C.A., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., Haasemann M., Hatat D., Hegemann J., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jackman P., Jacq C., Jacquet M., Jam es C.M., Jauniaux J.C., Jia Y., Jimenez A., Kleinhans U., Kreisl P., Lafranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat C., Mannhaupt G., Manzano M.E., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.W., Molemans F., Montague M.A., Navas L., Newlon C.S., Olson M.V., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschläger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Triano L.N., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Volckaert G., Vreken P., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Zimmermann F.K. and Sgouros J.G.

Manchester Biotechnology Centre, U MIST, UK.

The entire DNA sequence of chromosome III of the yeast Saccharomyces cerevisiae has been determined. This is the first complete sequence analysis of an entire chromosome from any organism. The 315-kilobase sequence reveals 182 open reading frames for proteins longer than 100 amino acids, of which 37 correspond to known genes and 29 more show some similarity to sequences in databases. Of 55 new open reading frames analysed by gene disruption, three are essential genes; of 42 non-essenti al genes that were tested, 14 show some discernible effect on phenotype and the remaining 28 have no overt function.


Note: The current version of chromosome III has been updated since its release in 1992 at several positions. See the WWW pages at http://vms.mips.biochem.mpg.de/yeast_data/three for the current version.


EMBL accession number: X59720