Yeast - Physiological and Genetic Pathways


PKC Pathway and Response to Low Osmolarity

The PKC pathway controls cell integrity. The PKC MAPK cascade is activated in response to heat and low osmotic stress and nutrient limitation. Hcs77 is a putative mechanosensor that is proposed to sense membrane stretch. Pkc1p is proposed to activate a branched pathway (one branch is the MAPK and the other is hypothetical). Rlm1p appears to be a target for Mpk1p. Solid arrows indicate activation; the dashed arrow is speculative. For further information see:

Signalling in the yeasts: an informational cascade with links to the filamentous fungi.
Microbiology and Molecular Biology Reviews 62(2): 249-274 (1998)

This page was kindly provided by Flora Banuett

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Generated Fri Februaryy 5 1999 Uli Oechsner Last modified: Tue Feb 10 10:02:30 CET 2004