Yeast - Physiological and Genetic Pathways

mips


Control of the GAL genes by glucose in a gal80 background

Click the appropriate protein or complex name to get information about the corresponding protein or complex.
This page was kindly provided by Juana M. Gancedo
Gancedo, M. Juana
Yeast Carbon Catabolite Repression
Microbiology and Molecular Biology Review 62:334-361 (1998)



Control of the GAL genes by glucose in a gal80 background. In the presence of glucose, the Mig1 complex is active and decreases the rate of synthesis of GAL4 mRNA. The resulting low level of Gal4, together with the repressing effect of the Mig1 complex, leads to a very low level of expression of the GAL genes. For the Mig1 complex to exert its repressing activity, the Glc7 complex and elements in the glucose signalling pathway, such as Grr1 and Hxk2, are required. In the absence of glucose, the Snf1 complex is activated and is able to release repression by Mig1; this allows maximal expression of GAL4, and the elevated levels of Gal4, together with the lack of activity of Mig1, turn on completely the expression of the GAL genes.

Generated Thu May 28 1998 Last modified: Tue Feb 10 10:08:28 CET 2004