Click the appropriate gene name to get information about the corresponding protein of the pathway
This page was kindly provided by Patrick O. Brown
See DeRisi,J.L. et al.
Exploring the metabolic and genetic control of gene expression on a genomic scale.
Science 278:680-686 (1997)
Metabolic reprogramming inferred from global analysis of changes in gene
expression. Only key metabolic intermediates are identified. The yeast
genes encoding the enzymes that catalyze each step in this metabolic circuit
are identified by name in the boxes. The genes encoding succinyl CoA synthase
and glycogen debranching enzyme have not been explicitly identified, but the
ORFs YGR244 and YPR184 show significant homology to known succinyl CoA
synthase and glycogen debranching enzymes, respectively, and are therefore
included in the corresponding steps in this figure. Red boxes with white
lettering identify genes whose expression increases in the diauxic shift.
Green boxes, with dark green lettering, identify genes whose expression
diminishes in the diauxic shift. The magnitude of induction or repression
is indicated for these genes. For multimeric enzyme complexes, such as
succinate dehydrogenase, the indicated fold-induction represents an unweighted
average of all the genes listed in the box. Black and white boxes indicate no
significant differential expression (less than 2 fold). The direction of the
arrows connecting reversible enzymatic steps indicate the direction of the
flow of metabolic intermediates, inferred from the gene expression pattern,
following the diauxic shift. Arrows representing steps catalyzed by genes
whose expression was strongly induced are highlighted in red. The broad gray
arrows represent major increases in the flow of metabolites following the
diauxic shift, inferred from the indicated changes in gene expression.
Generated Thu Nov 20 1997