Yeast Physiological and Genetic Pathways

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Model for the role of Cdc5p, Cdc20p and Hct1p in APC-mediated ubiquitination

Click the appropriate protein name to get information about the corresponding protein of the pathway.
This page was kindly provided by Masaki Shirayama


See Shirayama,M. et al.
EMBO J. 17:1336-1349 (1998)




Model for the role of the Polo kinase Cdc5p and the WD40 repeat proteins Cdc20p and Hct1/Cdh1p in APC-mediated ubiquitination.

Cdc20p is required for ubiquitination by the APC of the 'early' substrates such as an inhibitor of anaphase. Cdc5p is required to activate Hct1/Cdh1p-dependent ubiquitination of 'late' substrates such as Clb2p, whose degradation is important for exit from mitosis. Cdc5p and Cdc20p are themselves substrates of the APC.


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