Yeast - Physiological and Genetic Pathways


Proteolytic paths involved in cell cycle control

Click the appropriate protein or complex name to get information about the corresponding protein or complex.
This page was kindly provided by Michele Pagano
Slingerland,J. and Pagano,M
Regulation of the cell cycle by the ubiquitin pathway
in: Cell cycle control 22:133-147 (1998)
Ed. M.Pagano, Springer Verlag

Proteolytic paths involved in cell cycle control. The phosphorylation of both G1 cyclins, Clns 1 and 2, and of the CDK inhibitor, Sic1, triggers their recognition by multiprotein E2/E3 complexes. The E2, Cdc34, binds an ubiquitin ligase (E3) complex which includes Cdc53, Skp1 and Grr1, for the Clns, and Cdc53, Skp1 and Cdc4, in the case of Sic1. The anaphase promoting complex, or APC, is a multiprotein E3 complex which regulates the G2/M transition. The APC is regulated by proteins which may include cyclin B/CDK1, Cdc20 and PKA. DNA damage, spindle defects and incompletely replicated DNA inhibit APC activation. APC-mediated degradation of Pds1 is required for anaphase progression and APC-mediated degradation of cyclin B is required for the exit from mitosis. APC action on B-type cyclins is regulate by the Dbf2 group of protein kinases. The APC remains active until it is inactivated at START in a Cln/Cdc28-dependent manner.
Generated Thu May 28 1998 Last modified: Tue Feb 10 10:20:35 CET 2004