Yeast Physiological and Genetic Pathways

mips


Model for the import of mitochondrial carrier proteins

Click the appropriate protein name to get information about the corresponding protein of the pathway.
This page was kindly provided by Carla M. Koehler


See:
Koehler, C.M. et al. (1998)
Import of mitochondrial carriers mediated by essential proteins of the intermembrane space.
Science 279:369-373

Koehler, C.M. et al. (1998)
Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins.
EMBO-J. 17:6477-6486




The TIM complexes mediating import of mitochondrial carrier proteins.

Outer membrane (OM) proteins 5, 6, 7, 20, 22, 37, 40, and 70 are subunits of the TOM system that transports proteins across the outer membrane. Proteins 9, 10, 12, 22 and 54 are subunits of the TIM system that mediates import of multispanning carrier proteins into the inner membrane (IM). A carrier precursor exiting the TOM channel is captured by the 70 kDa Tim9/10-complex in the intermembrane space and transferred to the 300 kDa inner membrane complex that contains Tim9p, Tim10p, Tim12p, Tim22p and Tim54p. Binding to the Tim22-complex triggers the membrane potential dependent insertion of mulitspanning carrier into the inner membrane. Inner membrane proteins 11, 17, 23 and 44 are members of, or closely adjacent to, the second TIM system (Tim17-complex)that mediates transport of precursors carrying a targeting presequence.

Generated Wed Feb 25 1998
Updated Tue Dec 15 1998
Last modified: Tue Feb 10 10:23:36 CET 2004