Yeast - Physiological and Genetic Pathways


Biosynthesis of sphingolipids in S.cerevisiae

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Adapted from F. Reggiori and A. Conzelmann
Biosynthesis of inositol phosphoceramides and remodeling of glycosylphosphatidyl anchors in Saccharomyces cerevisiae are mediated by different enzymes.
J Biol Chem 273: 30550-30559 (1998)

Schematic representation of the biosynthesis of sphingolipids in S.cerevisiae.

Abbreviations used:

GPI, glycosylphosphatidylinositol; Cer, ceramide; Cer-P, ceramide phosphate; DAG, diacylglycerol; DHS, dihydrosphingosine; IPC, inositol phosphoceramide; MIPC, mannosylinositol phosphoceramide; M(IP)2C, inositol phospho-MIPC; PHS, phytosphingosine; PI, phosphatidylinositol;

Last modified: Tue Feb 10 10:26:42 CET 2004