Summary of the yeast Krebs tricarboxylic acid cycle
Click the appropriate gene name to get information about the corresponding protein of the pathway
This page was kindly provided by Mark T. McCammon
See Przybyla-Zawislak, B., Gadde, D. M., Ducharme, K., and McCammon, M. T.
Genetic and biochemical interactions involving tricarboxylic acid
cycle function: a collection of mutants defective in all TCA cycle genes.
Genetics 152, 153-166 (1999)
The yeast tricarboxylic acid cycle.
The eight enzymes of the Krebs tricarboxylic acid (TCA) cycle are encoded by
at least fifteen genes in S. cerevisiae. The gene(s) encoding a TCA cycle
enzyme are shown in the center. The number of different subunits are
indicated by multiple genes, however, the oligomeric state of an enzyme is
not indicated (e.g., a4b4 for NAD-IDH). Enzyme (abbreviation), gene
(Saccharomyces cerevisiae locus): citrate synthase (CS-1), CIT1 (YNR001c);
aconitase, ACO1 (YLR304c); NAD+-dependent isocitrate dehydrogenase
(NAD-IDH), IDH1 (YNL037c), IDH2 (YOR136w); a-ketoglutarate (2-oxoglutarate)
dehydrogenase complex (KGDC), KGD1 (YIL125w), KGD2 (YDR148c), LPD1
(YFL018c); succinyl-CoA ligase (synthetase), LSC1 (YOR142w), LSC2 (YGR244c);
succinate dehydrogenase (SDH), SDH1 (YKL148c), SDH2 (YLL041c), SDH3
(YKL141w), SDH4 (YDR178w); fumarase, FUM1 (YPL262w); malate dehydrogenase
(MDH-1), MDH1 (YKL085c). Genes shown by enzyme name encode open reading
frames with significant homology to an inner gene. The contributions of
these outer genes to TCA cycle function are not well understood. CIT3
(YPR001w); ACO2 (YJL200c); SDH1B (YJL045c), SDH3B (YMR118c), SDH4B
(YLR164w), SDH4C (YOR297c). The gene assignments for SDH3B, SDH4B, and SDH4C
are tentative pending characterization.
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Last modified: Tue Feb 10 10:28:14 CET 2004