Yeast Physiological and Genetic Pathways


Summary of the yeast Krebs tricarboxylic acid cycle

Click the appropriate gene name to get information about the corresponding protein of the pathway
This page was kindly provided by Mark T. McCammon

See Przybyla-Zawislak, B., Gadde, D. M., Ducharme, K., and McCammon, M. T.
Genetic and biochemical interactions involving tricarboxylic acid cycle function: a collection of mutants defective in all TCA cycle genes.
Genetics 152, 153-166 (1999)

The yeast tricarboxylic acid cycle. The eight enzymes of the Krebs tricarboxylic acid (TCA) cycle are encoded by at least fifteen genes in S. cerevisiae. The gene(s) encoding a TCA cycle enzyme are shown in the center. The number of different subunits are indicated by multiple genes, however, the oligomeric state of an enzyme is not indicated (e.g., a4b4 for NAD-IDH). Enzyme (abbreviation), gene (Saccharomyces cerevisiae locus): citrate synthase (CS-1), CIT1 (YNR001c); aconitase, ACO1 (YLR304c); NAD+-dependent isocitrate dehydrogenase (NAD-IDH), IDH1 (YNL037c), IDH2 (YOR136w); a-ketoglutarate (2-oxoglutarate) dehydrogenase complex (KGDC), KGD1 (YIL125w), KGD2 (YDR148c), LPD1 (YFL018c); succinyl-CoA ligase (synthetase), LSC1 (YOR142w), LSC2 (YGR244c); succinate dehydrogenase (SDH), SDH1 (YKL148c), SDH2 (YLL041c), SDH3 (YKL141w), SDH4 (YDR178w); fumarase, FUM1 (YPL262w); malate dehydrogenase (MDH-1), MDH1 (YKL085c). Genes shown by enzyme name encode open reading frames with significant homology to an inner gene. The contributions of these outer genes to TCA cycle function are not well understood. CIT3 (YPR001w); ACO2 (YJL200c); SDH1B (YJL045c), SDH3B (YMR118c), SDH4B (YLR164w), SDH4C (YOR297c). The gene assignments for SDH3B, SDH4B, and SDH4C are tentative pending characterization.

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