'GT-AG rule'

Nearly all hemiascomycetous yeast introns begin with 'GT' and end with 'AG' [Bon et al., 2003], whereas introns beginning with 'GC' are exceptional [Spingola et al., 1999], like in S. pombe and other eukaryotes [Wood et al., 2002].

The predominance of this 'GT-AG' rule supports the hypothesis that spliceosomal introns are spliced in yeasts, as in most eukaryotes, by a conserved mechanism.

Last modified: Tue Feb 10 11:04:10 CET 2004